IL-4 Monoclonal Antibody (B-S4), FITC, eBioscience
PRODUCT DETAILS
Host: Mouse
Isotype: IgG1
Clonality: Monoclonal
Clone: B-S4
Format: FITC
Reactivity: Hu
Application: Flow Cytometry
Tested Dilution: Assay-Dependent
Concentration: 10 μL/Test
Storage: 4°C, store in dark
Formulation: TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Purification: Affinity chromatography
Data Sheet: TDS
Specific Information
Description: IL-4 (B-S4) is a mouse monoclonal antibody raised against IL-4 of humanorigin.
BMS129FI is suitable for intracellular staining of IL-4.
Human IL-4 exists in molecular weight forms between 15,000 and 19,000 daltons, representing variable glycosylation. The gene for human IL-4 is found on the long arm of chromsome 5 in close association with genes for IL-13, IL-5 GM-CSF and IL-3.IL-4 mediates its function by binding to receptors expressed on target cells. The IL-4 receptors exhibit an affinity of approximately 10-10 M. Receptors exist on freshly prepared B and T lymphocytes and macrophages, as well as on various cell lines including lymphoid cells, mast cell lines, a variety of other hematopoietic cell lines, fibroblasts and stromal cell lines. On T and B cells, receptors are present in low numbers (appr. 400), which are reported to be up-regulated by IL-2 and IL-4.
IL-4 is produced by a particular subset of T helper cells, the TH2 cells. These cells tend to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). Apart from T cells, it has been shown that mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. It can promote survival, growth, and differentiation of both T and B lymphocytes, mast cells, and endothelial cells. In addition, IL-4 can inhibit the production of TNF, IL-1, and IL-6 by macrophages.
Applications Tested: Flow Cytometry (Intracellular Staining).
Purity: >95%.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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IL-4 Monoclonal Antibody (B-S4), FITC, eBioscience
IL-4 Monoclonal Antibody (B-S4), FITC, eBioscience
PRODUCT DETAILS
Host: Mouse
Isotype: IgG1
Clonality: Monoclonal
Clone: B-S4
Format: FITC
Reactivity: Hu
Application: Flow Cytometry
Tested Dilution: Assay-Dependent
Concentration: 10 μL/Test
Storage: 4°C, store in dark
Formulation: TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Purification: Affinity chromatography
Data Sheet: TDS
Specific Information
Description: IL-4 (B-S4) is a mouse monoclonal antibody raised against IL-4 of humanorigin.
BMS129FI is suitable for intracellular staining of IL-4.
Human IL-4 exists in molecular weight forms between 15,000 and 19,000 daltons, representing variable glycosylation. The gene for human IL-4 is found on the long arm of chromsome 5 in close association with genes for IL-13, IL-5 GM-CSF and IL-3.IL-4 mediates its function by binding to receptors expressed on target cells. The IL-4 receptors exhibit an affinity of approximately 10-10 M. Receptors exist on freshly prepared B and T lymphocytes and macrophages, as well as on various cell lines including lymphoid cells, mast cell lines, a variety of other hematopoietic cell lines, fibroblasts and stromal cell lines. On T and B cells, receptors are present in low numbers (appr. 400), which are reported to be up-regulated by IL-2 and IL-4.
IL-4 is produced by a particular subset of T helper cells, the TH2 cells. These cells tend to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). Apart from T cells, it has been shown that mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. It can promote survival, growth, and differentiation of both T and B lymphocytes, mast cells, and endothelial cells. In addition, IL-4 can inhibit the production of TNF, IL-1, and IL-6 by macrophages.
Applications Tested: Flow Cytometry (Intracellular Staining).
Purity: >95%.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Original: $318.00
-70%$318.00
$95.40Product Information
Product Information
Shipping & Returns
Shipping & Returns
Description
PRODUCT DETAILS
Host: Mouse
Isotype: IgG1
Clonality: Monoclonal
Clone: B-S4
Format: FITC
Reactivity: Hu
Application: Flow Cytometry
Tested Dilution: Assay-Dependent
Concentration: 10 μL/Test
Storage: 4°C, store in dark
Formulation: TBS with 1% BSA and 0.02% sodium azide; pH 7.2-7.4
Purification: Affinity chromatography
Data Sheet: TDS
Specific Information
Description: IL-4 (B-S4) is a mouse monoclonal antibody raised against IL-4 of humanorigin.
BMS129FI is suitable for intracellular staining of IL-4.
Human IL-4 exists in molecular weight forms between 15,000 and 19,000 daltons, representing variable glycosylation. The gene for human IL-4 is found on the long arm of chromsome 5 in close association with genes for IL-13, IL-5 GM-CSF and IL-3.IL-4 mediates its function by binding to receptors expressed on target cells. The IL-4 receptors exhibit an affinity of approximately 10-10 M. Receptors exist on freshly prepared B and T lymphocytes and macrophages, as well as on various cell lines including lymphoid cells, mast cell lines, a variety of other hematopoietic cell lines, fibroblasts and stromal cell lines. On T and B cells, receptors are present in low numbers (appr. 400), which are reported to be up-regulated by IL-2 and IL-4.
IL-4 is produced by a particular subset of T helper cells, the TH2 cells. These cells tend to make a specific set of lymphokines including IL-4, IL-5, IL-6, IL-10, IL-13, IL-3 and GM-CSF and fail to produce IL-2, IFN-gamma, and lymphotoxin (TNF-beta). Apart from T cells, it has been shown that mast cells can produce IL-4. IL-4 exerts numerous effects on various hematopoietic cell types. On B cells, IL-4 promotes immunological class switching to IgE and IgG1 isotypes and upregulates MHC class II and CD23 expression. It can promote survival, growth, and differentiation of both T and B lymphocytes, mast cells, and endothelial cells. In addition, IL-4 can inhibit the production of TNF, IL-1, and IL-6 by macrophages.
Applications Tested: Flow Cytometry (Intracellular Staining).
Purity: >95%.
Excitation: 488 nm; Emission: 520 nm; Laser: Blue Laser
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
